class: center, middle, inverse, title-slide # Psychological Traits in Okazaki Cohort Study ## a Genome Wide Association Study ### Chaochen Wang ### 王 超辰 --- class: center, middle # 注意欠陥・多動性障害 # ADHD ## ASRS<sup>[1]</sup> .footnote[ [1] Psychol Med. 2005 Feb;35(2):245-56. ] --- class: middle, center background-image: url(fig/ASRS1MHplot.png) background-size: contain --- class: middle, center background-image: url(fig/ASRS1qqplot.png) background-size: contain --- class: center, middle # 自閉症 # Autism ## SATQ<sup>[1]</sup> .footnote[ [1] J Autism Dev Disord. 2012 May;42(5):769-80. ] --- class: middle, center background-image: url(fig/SATQMHplot.png) background-size: contain --- class: middle, center background-image: url(fig/SATQQplot.png) background-size: contain --- class: center, middle # 抑うつ・不安 # Distress ## K6<sup>[1]</sup> .footnote[ [1] [Kessler Psychological Distress Scale (K6)](http://www.statisticssolutions.com/kessler-psychological-distress-scale-k6/) ] --- class: middle, center background-image: url(fig/K6MHplot.png) background-size: contain --- class: middle, center background-image: url(fig/K6QQplot.png) background-size: contain --- class: center, middle # アレキシサイミア # (感情を認知することの障害) # Alexithymia ## TAS20<sup>[1]</sup> .footnote[ [1] [Toronto Alexithymia Scale (TAS-20)](https://contextualscience.org/TAS_Measure) ] --- class: middle, center background-image: url(fig/TAS20MHplot.png) background-size: contain --- class: middle, center background-image: url(fig/TAS20QQplot.png) background-size: contain --- class: center, middle # Multiple phenotype analysis ## [mvBIMBAM](https://github.com/heejungshim/mvBIMBAM) --- class: middle, center #### Table 1. Summary of Psycological Traits in Okazaki Cohorts ``` ## ## Overall ## n 828 ## SATQ (mean (sd)) 39.15 (4.19) ## TAS20 (mean (sd)) 49.56 (9.73) ## K6 (mean (sd)) 3.09 (3.32) ## Sleep (mean (sd)) 6.58 (1.09) ``` #### Table 2. Summary of Correlation Coefficients Among above traits ``` ## r statistic pvalue lower upper ## ASRS&SATQ -0.02723 -0.780 4.36e-01 -0.0955 0.04126 ## ASRS&K6 0.56929 19.816 1.07e-71 0.5212 0.61380 ## ASRS&TAS20 0.39188 12.160 2.20e-31 0.3322 0.44842 ## ASRS&Sleep -0.06267 -1.793 7.34e-02 -0.1307 0.00595 ## SATQ&K6 -0.04338 -1.244 2.14e-01 -0.1114 0.02503 ## SATQ&TAS20 0.00746 0.214 8.31e-01 -0.0609 0.07575 ## SATQ&Sleep 0.04155 1.190 2.34e-01 -0.0269 0.10966 ## K6&TAS20 0.46285 14.925 1.01e-44 0.4073 0.51503 ## K6&Sleep -0.14825 -4.287 2.02e-05 -0.2145 -0.08060 ## TAS20&Sleep -0.06301 -1.803 7.18e-02 -0.1310 0.00560 ``` --- class: middle, center #### Table 3. Summary of Correlation Coefficients Among previous mentioned traits <table border='3' cellpadding='6' align="center" style="margin: 0px auto;"> <tr> <td> ASRS </td> <td> -0.028 <br> (-0.096 ~ 0.041) </td> <td> 0.513 <br> (0.461 ~ 0.562) </td> <td> 0.403 <br> (0.344 ~ 0.459) </td> <td> -0.014 <br> (-0.082 ~ 0.055) </td> </tr> <tr> <td> </td> <td> SATQ </td> <td> -0.043 <br> (-0.111 ~ 0.025) </td> <td> 0.007 <br> (-0.061 ~ 0.076) </td> <td> 0.042 <br> (-0.027 ~ 0.110) </td> </tr> <tr> <td> </td> <td> </td> <td> K6 </td> <td> 0.487 <br> (0.433 ~ 0.538) </td> <td> -0.118 <br> (-0.185 ~ -0.050) </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> TAS20 </td> <td> -0.063 <br> (-0.131 ~ 0.006) </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> Sleep </td> </tr> </table> --- class: middle ```yaml ##### BIMBAM multiphenotypes analysis################ for i in 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 do ./bimbam -gmode 1 -g /home/takeshi/GWAS/Okazaki/BIMBAMdata/chr${i}geno.txt -p example/bimbam5pheno807.txt -o chr${i}.mph2 -f 5 -mph 2 -A 0.1 -A 0.2 done ``` <br> <br> <br> ``` ## CHR POS CHRM.POS log10BayesFactor_any log10BayesFactor_multi ## 1 14 56704837 14:56704837 10.5 10.8 ## 2 4 114904373 4:114904373 10.6 10.9 ## SATQ ASRS1 K6 Sleep TAS20 MAF ## 1 11.3 -0.071 -0.0761 -0.0710 1.56 0.319 ## 2 11.5 -0.085 -0.0925 -0.0852 1.52 0.114 ``` --- class: middle, center background-image: url(fig/BIMBAMMHplot.png) background-size: contain